基本介绍

段成国

教授、博士生导师（招生专业：植物保护、生物学等）

 

专业方向

  1. 植物-病原微生物互作的表观遗传调控机制；
  2. 作物抗病基因挖掘与病害致病机理；
  3. 植物病害新型绿色防控技术开发。

课题组长期招聘博士后，欢迎具有相关研究背景的应聘者来信咨询。

 

人才项目

2026：中山大学逸仙学者优秀学者

2022：入选中国科学院“特聘研究骨干”

2018：入选“国家海外高层次人才引进计划青年项目”

 

教育经历

2004-2008，中国科学院微生物研究所，博士

1997-2004，山东农业大学，本科、硕士

 

工作经历

2026.04-至今，中山大学，yl1111永利集团，教授

2020.04-2026.03，中国科学院分子植物科学卓越创新中心，研究员

2016.11-2020.03，中国科学院上海生命科学研究院植物逆境生物学研究中心，研究员

2011.11-2016.10，美国普渡大学，博士后

2008.07-2011.10，中国科学院微生物研究所，助理研究员

 

科研成果

实验室长期聚焦植物-病原微生物互作的表观调控机理研究，在DNA与组蛋白修饰、小RNA与RNA修饰的分子机制解析及其对植物-病原互作的调控领域取得了一系列重要成果（ORCID主页: https://orcid.org/0000-0003-0527-5866）。代表性成果包括解析组蛋白H3K4/K9/K27甲基化建立的分子机制及其对植物免疫的调控、解析植物DNA甲基化与去甲基化的分子机制、解析小RNA与RNA修饰介导的植物-病原互作机制、发现首个病原真菌编码的植物跨界RNAi抑制子、揭示植物病毒病和黄萎病分子致病机理等。累计发表SCI 论文60余篇，引用5000余次，其中在Nat Commun (3)、PNAS (3)、Mol Plant、New Phytologist、JIPB (4)等期刊发表通讯（含共同）作者论文24篇，在Cell Research、PNAS、Plant Cell、EMBO J等期刊发表第一（含共同）作者论文13篇。作为副主编撰写《小RNA-植物生命过程的关键密码》一部。

 

发表论文

通讯/共通讯作者(*)

  1. Liu JH, Yu H*, Duan CG*. The expanding role of m6A RNA modification in plant-virus dynamics: friend, foe, or both? Advanced Biotechnology. 2026, 4 (1): 7
  2. Liu JH#, Lin Y#, Li YX, Lang Z, Zhang Z, Duan CG*. A mutually antagonistic mechanism mediated by RNA m6A modification in plant-virus interactions. Nature Communications. 2025, 16 (1): 10378.
  3. Zhang YC, Zhan X, Chen JY, Yu DT, Zhang T, Zhang H, Duan CG*. Reduced fungal protein acetylation mediates the antimicrobial activity of a rhizosphere bacterium against a phytopathogenic fungus. Nature Communications. 2025, 16 (1): 5644. 
  4. Chen JY#, Zhang PY#, Duan CG*. Complex of proteins associated with Set1 complexes and their increasing roles in crop improvement. Current Opinion in Plant Biology. 2025, 88: 102788. 
  5. Zhang H, Yang Q, Wang L, Liu H, Zhang D, Duan CG*, Li X*. Moss-pathogen interactions: a review of the current status and future opportunities. Frontier in Genetics. 2025, 16:1539311
  6. Xue Y*, Cao X*, Chen X*, Deng X*, Deng XW*, Ding Y*, Dong A*, Duan CG*,……Liu Q*. Epigenetics in the modern era of crop improvements. Science China Life Science. 2025, 68 (6): 1570-1609. 
  7. Zhang J#, Yuan J#, Lin J#, Chen L, You LY, Chen S, Peng L, Wang CH, Du J*, Duan CG*. Molecular basis of locus-specific H3K9 methylation catalyzed by SUVH6 in plants. Proceedings of the National Academy of Sciences of USA. 2023, 120 (1): e2208525120. 
  8. Xie SS#, Zhang YZ#, Peng L, Yu DT, Zhu G, Zhao Q, Wang CH, Xie Q, Duan CG*. JMJ28 guides sequence-specific targeting of ATX1/2-containing COMPASS-like complex in Arabidopsis. Cell Reports. 2023, 42 (3): 112163. 
  9. Chen YY#, Zhu C#, Zhao JH, Liu T, Gao F, Zhang YC, Duan CG*. DNA methylation-dependent epigenetic regulation of Verticillium dahliae virulence in plants. aBIOTECH. 2023, 4 (3): 185-201. 
  10. Xie SS, Duan CG*. Epigenetic regulation of plant immunity: from chromatin codes to plant disease resistance. aBIOTECH. 2023, 4 (2): 124-139. 
  11. Liu T, Xu LG, Duan CG*. The trans-kingdom communication of noncoding RNAs in plant-environment interactions. Plant Genome. 2022, e20289.
  12. Chang YN#, Wang Z#, Ren Z, Wang CH, Wang P, Zhu JK, Li X*, Duan CG*. NUCLEAR PORE ANCHOR and EARLY IN SHORT DAYS 4 negatively regulate abscisic acid signaling by inhibiting Snf1-related protein kinase 2 activity and stability in Arabidopsis. Journal of Integrative Plant Biology. 64 (11): 2060-2074. 
  13. Zhu C#, Liu JH#, Zhao JH, Liu T, Chen YY, Wang CH, Zhang ZH, Guo HS, Duan CG*. A fungal effector suppresses the nuclear export of AGO1-miRNA complex to promote infection in plants. Proceedings of the National Academy of Sciences of USA. 2022, 119 (12): e2114583119. 
  14. You LY#, Lin J#, Xu HW#, Chen CX, Chen JY, Zhang J, Zhang J, Li YX, Ye C, Zhang H, Jiang J, Zhu JK, Li QQ*, Duan CG*. Intragenic heterochromatin-mediated alternative polyadenylation modulates miRNA and pollen development in rice. New Phytologist. 2021, 232 (2): 835-852. 
  15. Zhang YZ#, Lin J#, Ren Z#, Chen CX#, Miki D#, Xie SS, Zhang J, Chang YN, Jiang J, Yan J, Li QQ*, Zhu JK*, Duan CG*. Genome-wide distribution and functions of the AAE complex in epigenetic regulation in Arabidopsis. Journal of Integrative Plant Biology. 2021, 63 (4): 707-722.
  16. Zhang YZ#, Yuan J#, Zhang L#, Chen C, Wang Y, Zhang G, Peng L, Xie SS, Jiang J, Zhu JK, Du J*, Duan CG*. Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex in Arabidopsis. Nature Communications. 2020, 11 (1): 6212. 
  17. Zhang J, Zhang YZ, Jiang J, Duan CG*. The crosstalk between epigenetic mechanisms and alternative RNA processing regulation. Frontiers in Genetics.2020, 11: 998.
  18. Chang YN, Zhu C, Jiang J, Zhang H, Zhu JK, Duan CG*. Epigenetic regulation in plant abiotic stress responses. Journal of Integrative Plant Biology. 2020, 62 (5): 563-580. (高引论文)
  19. Cui C#, Wang JJ#, Zhao JH#, Fang YY, He XF, Guo HS*, Duan CG*. A brassica miRNA regulates plant growth and immunity through distinct modes of action.Molecular Plant. 2020, 13 (2): 231-245. (高引论文)
  20. Zhu G, Chang YN, Xu X, Tang K, Chen C, Lei M, Zhu JK*, Duan CG*. EXPORTIN 1A prevents transgene silencing in Arabidopsis by modulating nucleo-cytoplasmic partitioning of HDA6. Journal of Integrative Plant Biology.2019, 61 (12): 1243-1254. 
  21. Zhu C, Liu T, Chang YN, Duan CG*. Small RNA functions as a trafficking effector of plant immunity. International Journal of Molecular Science. 2019, 20 (11): 2816. 
  22. Duan CG*, Zhu JK*, Cao X*. Retrospective and perspective of plant epigenetics in China. Journal of Genetics and Genomics, 2018, 45 (11): 621-638 
  23. Duan CG#*, Wang X#, Zhang L, Xiong X, Zhang Z, Tang K, Pan L, Hsu CC, Xu H, Tao WA, Zhang H, Zhu JK*. A protein complex regulates RNA processing of intronic heterochromatin-containing genes in Arabidopsis. Proceedings of the National Academy of Sciences of USA 114 (35): 2017, 114(35): E7377-E7384
  24. Fang YY#, Zhao JH#, Liu SW, Wang S, Duan CG*, Guo HS*. CMV2b-AGO interaction is required for the suppression of RDR-dependent antiviral silencing in Arabidopsis. Frontiers in Microbiology, 2016, 7: 1329

第一/共第一作者(#)

  1. Duan CG#, Wang X#, Xie S, Pan L, Miki D, Tang K, Hsu CC, Lei M, Zhong Y, Hou YJ, Wang Z, Zhang Z, Mangrauthia SK, Xu H, Zhang H, Dilkes B, Tao WA, Zhu JK*. A pair of transposon-derived proteins function in a histione acetyltransferase complex for active DNA demethylation. Cell Research. 2017, 27: 226-240 
  2. Duan CG#, Zhang H#, Tang K#, Zhu X, Qian W, Hou YJ, Wang B, Lang Z, Zhao Y, Wang X, Wang P, Zhou J, Liang G, Liu N, Wang C, Zhu JK*. Specific but Interdependent Functions for Arabidopsis AGO4 and AGO6 in RNA-directed DNA Methylation. EMBO Journal, 2015, 34(5): 581-59 
  3. Duan CG#, Wang X#, Tang K, Zhang H, Mangrauthia SK, Lei M, Hsu CC, Hou YJ, Wang C, Li Y, Tao WA and Zhu JK*. MET18 Connects the Cytosolic Iron-Sulfur Cluster Assembly Pathway to Active DNA Demethylation in Arabidopsis. PLoS Genetics, 2015, 11(10): e1005559 
  4. Li Y#, Duan CG#, Zhu X., Qian W. and Zhu JK*. A DNA ligase required for active DNA demethylation and genomic imprinting in Arabidopsis. Cell Research, 2015, 25(6): 757-760
  5. Wang X#, Duan CG#, Tang K, Wang B, Zhang H, Lei M, Lu K, Mangrauthia SK, Wang P, Zhu G, Zhao Y and Zhu JK*. RNA-binding protein regulates plant DNA methylation by controlling Mrna processing at the intronic heterochromatin- containing gene IBM1. Proceedings of the National Academy of Sciences of USA, 2013, 110(38): 15467-15472
  6. Feng L#, Duan CG# and Guo HS*. Inhibition of in vivo Slicer activity of Argonaute protein 1 by the viral 2b protein independent of its dsRNA-binding function. Molecular Plant Pathology,2013,14(6): 617-622
  7. Duan CG#, Fang YY#, Zhou BJ, Zhao JH, Hou WN, Zhu H, Ding SW, and Guo HS*. Suppression of Arabidopsis ARGONAUTE1-mediated slicing, transgene-induced RNA silencing, and DNA methylation by distinct domains of the Cucumber mosaic virus 2b protein. Plant Cell, 2012, 24(1): 259-274
  8. Duan CG, Wang CH, and Guo HS*. Application of RNA silencing to plant disease resistance. Silence. 2012, 3(1): 5 
  9. Hou WN#, Duan CG#, Fang RX, Zhou XY, and Guo HS*. Satellite RNA reduces expression of the 2b suppressor protein resulting in the attenuation of symptoms caused by Cucumber mosaic virus infection. Molecular Plant Pathology, 2011, 12(6): 595-605 
  10. Duan CG, Wang CH, Fang RX, and Guo HS*. Artificial MicroRNAs highly accessible to targets confer efficient virus resistance in plants. Journal of Virology, 2008, 82(22): 11084-11095
  11. Duan CG, Wang CH & Guo HS*. Delayed resistance to Cucumber Mosaic Virus mediated by 3’UTR-derived hairpin RNA. Chinese Science Bulletin. 2008, 53 (21): 3301-3310
  12. Du QS#, Duan CG#, Zhang ZH#, Fang YY, Fang RX, Xie Q, and Guo HS*. DCL4 targets Cucumber mosaic virus satellite RNA at novel secondary structures. Journal of Virology, 2007, 81(17): 9142-9151
  13. Duan CG, Wang CH & Guo HS*. Regulation of microRNA on plant development and viral infection. Chinese Science Bulletin, 2006, 51(3): 269-278

 

科研项目：

  1. 国家重点研发计划项目（课题负责人，2024.12-2027.11）
  2. 国家自然科学基金面上项目（主持人，2026.01-2029.12）
  3. 国家自然科学基金面上项目（主持人，2023.01-2026.12）
  4. 植物性状形成与塑造全国重点实验室自由探索项目（主持人，2023.09-2025.12）
  5. 中国科学院战略先导科技专项（子课题负责人，2018.06-2023.06）
  6. 中组部“国家海外高层次人才引进计划青年项目”（2018.02-2020.12）
  7. 国家自然科学基金面上项目（主持人，2018.01-2021.12）
  8. 中国科学院上海分院青年博士后导师支持计划（主持人，2021.12-2023.11）
  9. 国家自然科学基金青年科学基金项目（主持人，2010.01-2012.12）

 

社会兼职

Epigenetics Insights栏目主编，The Crop Journal、aBIOTECH、Frontiers in Plant Sciences、植物资源与环境学报、生物技术通报编委